H2N2V1, Main, Exploration, bibRecord, 002A63

Immunogenicity and Reactogenicity of Influenza A/New Jersey/76 Virus Vaccines in Normal Adults

Identifieur interne : 002A63 ( Main/Exploration ); précédent : 002A62; suivant : 002A64

Immunogenicity and Reactogenicity of Influenza A/New Jersey/76 Virus Vaccines in Normal Adults

Auteurs : Raphael Dolin [États-Unis] ; Thomas G. Wise ; Mark H. Mazur ; Carme1ita U. Tuazon ; Francis A. Ennis

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1977.

RBID : ISTEX:F4594D8585C853EA3ED8B90AD231C779580C181C

Abstract

Inactivated influenza A/New Jersey/76 virus vaccines were administered intramuscularly to 199 normal adults, aged 19–59, in doses of 200, 400, or 800 chick cellagglutinating units in a double-blind, placebo-controlled trial. Systemic reactions (including fever) were uncommon, were mild, lasted <24 hr, and were more frequently associated with the largest dose. Local reactions were common but mild. A single, rapidly reversible, allergic reaction was noted in a volunteer 2 hr after vaccination. There was a trend toward fewer systemic reactions in vaccinees who had preexisting hemagglutination-inhibiting (HAl) antibodies to the vaccine virus in their sera as compared with seronegative vaccinees. All vaccine preparations at all three dosages evoked serum HAl titers of ⩾20 to ⩾40 in a high proportion of seronegative recipients, with significantly greater geometric mean titers at the highest dosage. Vaccinees between the ages of 19 and 23 years manifested significantly lower serologic responses than did vaccinees over the age of 23. Thus, normal adults over the age of 23 can be immunized with a single, well-tolerated dose of A/New Jersey /76 vaccines.

Url:

https://api.istex.fr/ark:/67375/HXZ-4K037WWK-8/fulltext.pdf

DOI: 10.1093/infdis/136.Supplement_3.S435

Affiliations:

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Le document en format XML

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</author>
<author><name sortKey="Wise, Thomas G" sort="Wise, Thomas G" uniqKey="Wise T" first="Thomas G." last="Wise">Thomas G. Wise</name>
</author>
<author><name sortKey="Mazur, Mark H" sort="Mazur, Mark H" uniqKey="Mazur M" first="Mark H." last="Mazur">Mark H. Mazur</name>
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<author><name sortKey="Tuazon, Carme1ita U" sort="Tuazon, Carme1ita U" uniqKey="Tuazon C" first="Carme1ita U." last="Tuazon">Carme1ita U. Tuazon</name>
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<author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name>
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<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
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<wicri:cityArea>Please address requests for reprints to Dr. Raphael Dolin, Medical Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
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<series><title level="j" type="main">Journal of Infectious Diseases</title>
<title level="j" type="abbrev">J Infect Dis.</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="1977-12">1977</date>
<biblScope unit="vol">136</biblScope>
<biblScope unit="issue">Supplemet_3</biblScope>
<biblScope unit="page" from="S435">S435</biblScope>
<biblScope unit="page" to="S442">S442</biblScope>
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<front><div type="abstract">Inactivated influenza A/New Jersey/76 virus vaccines were administered intramuscularly to 199 normal adults, aged 19–59, in doses of 200, 400, or 800 chick cellagglutinating units in a double-blind, placebo-controlled trial. Systemic reactions (including fever) were uncommon, were mild, lasted <24 hr, and were more frequently associated with the largest dose. Local reactions were common but mild. A single, rapidly reversible, allergic reaction was noted in a volunteer 2 hr after vaccination. There was a trend toward fewer systemic reactions in vaccinees who had preexisting hemagglutination-inhibiting (HAl) antibodies to the vaccine virus in their sera as compared with seronegative vaccinees. All vaccine preparations at all three dosages evoked serum HAl titers of ⩾20 to ⩾40 in a high proportion of seronegative recipients, with significantly greater geometric mean titers at the highest dosage. Vaccinees between the ages of 19 and 23 years manifested significantly lower serologic responses than did vaccinees over the age of 23. Thus, normal adults over the age of 23 can be immunized with a single, well-tolerated dose of A/New Jersey /76 vaccines.</div>
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<region><li>Maryland</li>
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<name sortKey="Mazur, Mark H" sort="Mazur, Mark H" uniqKey="Mazur M" first="Mark H." last="Mazur">Mark H. Mazur</name>
<name sortKey="Tuazon, Carme1ita U" sort="Tuazon, Carme1ita U" uniqKey="Tuazon C" first="Carme1ita U." last="Tuazon">Carme1ita U. Tuazon</name>
<name sortKey="Wise, Thomas G" sort="Wise, Thomas G" uniqKey="Wise T" first="Thomas G." last="Wise">Thomas G. Wise</name>
</noCountry>
<country name="États-Unis"><region name="Maryland"><name sortKey="Dolin, Raphael" sort="Dolin, Raphael" uniqKey="Dolin R" first="Raphael" last="Dolin">Raphael Dolin</name>
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Immunogenicity and Reactogenicity of Influenza A/New Jersey/76 Virus Vaccines in Normal Adults

Immunogenicity and Reactogenicity of Influenza A/New Jersey/76 Virus Vaccines in Normal Adults

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri